Affordable Drug Discovery
  • An Indian effort towards affordable drugs: “generic to designer drugs”. Taneja B, Yadav J, Chakraborty TK, Brahmachari SK. Biotechnol J. (2009) 4(3):348-360
  • Collaborative tools to accelerate neglected disease research: Open Source Drug Discovery model. Bhardwaj A, Scaria V, Thomas Z, Adayikkoth S, Open Source Drug Discovery (OSDD) Consortium, and Samir K. Brahmachari. Collaborative Computational Technologies for Biomedical Research (2011): 321-334, Eds. Sean Ekins, Maggie A. Z. Hupcey, Anthony Williams, John Wiley & Sons.
  • Towards new business models for R&D for novel antibiotics. So AD, Gupta N, Brahmachari SK, Chopra I, Munos B, Nathan C, Outterson K, Paccaud JP, Payne DJ, Peeling RW, Spigelman M, Weigelt J. Drug Resist Updat. (2011) 14(2):88-94
  • Open source drug discovery- A new paradigm of collaborative research in tuberculosis drug development. Bhardwaj A, Scaria V, Raghava GP, Lynn AM, Chandra N, Banerjee S, Raghunandanan MV, Pandey V, Taneja B, Yadav J, Dash D, Bhattacharya J, Misra A, Kumar A, Ramachandran S, Thomas Z, Brahmachari SK. Tuberculosis (Edinb). (2011) 91(5): 479-486.
  • Structural annotation of Mycobacterium tuberculosis proteome. Anand P, Sankaran S, Mukherjee S, Yeturu K, Laskowski R, Bhardwaj A, Bhagavat R; OSDD Consortium, Brahmachari SK, Chandra N. PLoS One. 2011;6(10):e27044. doi: 10.1371/journal.pone.0027044.
  • Crowd Sourcing a new paradigm for Interactome Driven Drug Target Identification in Mycobacterium tuberculosis. Vashisht R, Mondal AK, Jain A, Shah A, Vishnoi P, Priyadarshini P, Bhattacharyya K, Rohira, H, Bhat H, Passi A, Mukherjee K, Sonal K, Kumar V, Arora A, Munusamy P, Subramanian A, Venkatachalam A, Gayathri S, Raj S, Chitra V, Verma K, Zaheer S, Balganesh J, Gurusamy M, Mohammed Razeeth, Ilamathi Raja, Thandapani M, Mevada V, Soni R, Rana S, Girish MR, Raghavan S, Sunil N, Kholia T, Patel R, Bhavnani V, Chiranjeevi L, Sengupta S, Singh PK, Atray N, Gandhi S, Avasthi S, Nisthar S, Anurag M, Sharma P, Hasija Y, Dash D, Sharma A, Scaria V, Thomas Z, OSDD Consortium, Chandra N, Brahmachari SK and Bhardwaj A. PLoS One. 2012;7(7):e39808. doi: 10.1371/journal.pone.0039808.
  • An Indian effort towards affordable drugs: “generic to designer drugs”. Taneja B, Yadav J, Chakraborty TK, Brahmachari SK. Biotechnol J. (2009) 4(3):348-360
  • Collaborative tools to accelerate neglected disease research: Open Source Drug Discovery model. Bhardwaj A, Scaria V, Thomas Z, Adayikkoth S, Open Source Drug Discovery (OSDD) Consortium, and Samir K. Brahmachari. Collaborative Computational Technologies for Biomedical Research (2011): 321-334, Eds. Sean Ekins, Maggie A. Z. Hupcey, Anthony Williams, John Wiley & Sons.
  • Towards new business models for R&D for novel antibiotics. So AD, Gupta N, Brahmachari SK, Chopra I, Munos B, Nathan C, Outterson K, Paccaud JP, Payne DJ, Peeling RW, Spigelman M, Weigelt J. Drug Resist Updat. (2011) 14(2):88-94
  • Open source drug discovery- A new paradigm of collaborative research in tuberculosis drug development. Bhardwaj A, Scaria V, Raghava GP, Lynn AM, Chandra N, Banerjee S, Raghunandanan MV, Pandey V, Taneja B, Yadav J, Dash D, Bhattacharya J, Misra A, Kumar A, Ramachandran S, Thomas Z, Brahmachari SK. Tuberculosis (Edinb). (2011) 91(5): 479-486.
  • Structural annotation of Mycobacterium tuberculosis proteome. Anand P, Sankaran S, Mukherjee S, Yeturu K, Laskowski R, Bhardwaj A, Bhagavat R; OSDD Consortium, Brahmachari SK, Chandra N. PLoS One. 2011;6(10):e27044. doi: 10.1371/journal.pone.0027044.
  • Crowd Sourcing a new paradigm for Interactome Driven Drug Target Identification in Mycobacterium tuberculosis. Vashisht R, Mondal AK, Jain A, Shah A, Vishnoi P, Priyadarshini P, Bhattacharyya K, Rohira, H, Bhat H, Passi A, Mukherjee K, Sonal K, Kumar V, Arora A, Munusamy P, Subramanian A, Venkatachalam A, Gayathri S, Raj S, Chitra V, Verma K, Zaheer S, Balganesh J, Gurusamy M, Mohammed Razeeth, Ilamathi Raja, Thandapani M, Mevada V, Soni R, Rana S, Girish MR, Raghavan S, Sunil N, Kholia T, Patel R, Bhavnani V, Chiranjeevi L, Sengupta S, Singh PK, Atray N, Gandhi S, Avasthi S, Nisthar S, Anurag M, Sharma P, Hasija Y, Dash D, Sharma A, Scaria V, Thomas Z, OSDD Consortium, Chandra N, Brahmachari SK and Bhardwaj A. PLoS One. 2012;7(7):e39808. doi: 10.1371/journal.pone.0039808.
  • Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis. Ghosh S, Matsuoka Y, Asai Y, Kitano H, Bhardwaj A, Scaria V, Vashisht R, Shah A, Mondal AK, Vishnoi P, Sonal K, Jain A, Priyadarshini P, Bhattacharyya K, Kumar V, Passi A, Sharma P, Brahmachari SK. Systems Biology of Tuberculosis (2013), pp 21-35, Eds: Johnjoe McFadden, Dany J.V. Beste, Andrzej M. Kierzek, Springer
  • Social networks to biological networks: systems biology of Mycobacterium tuberculosis. Vashisht R, Bhardwaj A, OSDD Consortium, Brahmachari SK. Mol Biosyst, (2013), 9 (7): 1584 – 1593
  • Systems level mapping of metabolic complexity in Mycobacterium tuberculosis to identify high-value drug targets. Rohit Vashisht, Ashwini G Bhat, Shreeram Kushwaha, Anshu Bhardwaj, OSDD Consortium, Samir K Brahmachari. J Transl Med. 2014; 12(1): 263. doi: 10.1186/s12967-014-0263-5 PMCID: PMC4201925
  • An Indian effort towards affordable drugs: “generic to designer drugs”. Taneja B, Yadav J, Chakraborty TK, Brahmachari SK. Biotechnol J. (2009) 4(3):348-360
  • Collaborative tools to accelerate neglected disease research: Open Source Drug Discovery model. Bhardwaj A, Scaria V, Thomas Z, Adayikkoth S, Open Source Drug Discovery (OSDD) Consortium, and Samir K. Brahmachari. Collaborative Computational Technologies for Biomedical Research (2011): 321-334, Eds. Sean Ekins, Maggie A. Z. Hupcey, Anthony Williams, John Wiley & Sons.
  • Towards new business models for R&D for novel antibiotics. So AD, Gupta N, Brahmachari SK, Chopra I, Munos B, Nathan C, Outterson K, Paccaud JP, Payne DJ, Peeling RW, Spigelman M, Weigelt J. Drug Resist Updat. (2011) 14(2):88-94
  • Open source drug discovery- A new paradigm of collaborative research in tuberculosis drug development. Bhardwaj A, Scaria V, Raghava GP, Lynn AM, Chandra N, Banerjee S, Raghunandanan MV, Pandey V, Taneja B, Yadav J, Dash D, Bhattacharya J, Misra A, Kumar A, Ramachandran S, Thomas Z, Brahmachari SK. Tuberculosis (Edinb). (2011) 91(5): 479-486.
  • Structural annotation of Mycobacterium tuberculosis proteome. Anand P, Sankaran S, Mukherjee S, Yeturu K, Laskowski R, Bhardwaj A, Bhagavat R; OSDD Consortium, Brahmachari SK, Chandra N. PLoS One. 2011;6(10):e27044. doi: 10.1371/journal.pone.0027044.
  • Crowd Sourcing a new paradigm for Interactome Driven Drug Target Identification in Mycobacterium tuberculosis. Vashisht R, Mondal AK, Jain A, Shah A, Vishnoi P, Priyadarshini P, Bhattacharyya K, Rohira, H, Bhat H, Passi A, Mukherjee K, Sonal K, Kumar V, Arora A, Munusamy P, Subramanian A, Venkatachalam A, Gayathri S, Raj S, Chitra V, Verma K, Zaheer S, Balganesh J, Gurusamy M, Mohammed Razeeth, Ilamathi Raja, Thandapani M, Mevada V, Soni R, Rana S, Girish MR, Raghavan S, Sunil N, Kholia T, Patel R, Bhavnani V, Chiranjeevi L, Sengupta S, Singh PK, Atray N, Gandhi S, Avasthi S, Nisthar S, Anurag M, Sharma P, Hasija Y, Dash D, Sharma A, Scaria V, Thomas Z, OSDD Consortium, Chandra N, Brahmachari SK and Bhardwaj A. PLoS One. 2012;7(7):e39808. doi: 10.1371/journal.pone.0039808.
  • Software Platform for Metabolic Network Reconstruction of Mycobacterium tuberculosis. Ghosh S, Matsuoka Y, Asai Y, Kitano H, Bhardwaj A, Scaria V, Vashisht R, Shah A, Mondal AK, Vishnoi P, Sonal K, Jain A, Priyadarshini P, Bhattacharyya K, Kumar V, Passi A, Sharma P, Brahmachari SK. Systems Biology of Tuberculosis (2013), pp 21-35, Eds: Johnjoe McFadden, Dany J.V. Beste, Andrzej M. Kierzek, Springer
  • Social networks to biological networks: systems biology of Mycobacterium tuberculosis. Vashisht R, Bhardwaj A, OSDD Consortium, Brahmachari SK. Mol Biosyst, (2013), 9 (7): 1584 – 1593
  • Systems level mapping of metabolic complexity in Mycobacterium tuberculosis to identify high-value drug targets. Rohit Vashisht, Ashwini G Bhat, Shreeram Kushwaha, Anshu Bhardwaj, OSDD Consortium, Samir K Brahmachari. J Transl Med. 2014; 12(1): 263. doi: 10.1186/s12967-014-0263-5 PMCID: PMC4201925
  • Metformin as a potential combination therapy with existing front-line antibiotics for Tuberculosis. Rohit Vashisht and Samir K Brahmachari. JTransl Med. 2015; 13:83 doi: 10.1186/s12967-015-0443-y
  • Designing non-toxic ligands against TB using data intensive genome level analysis. D. Kaur, S. K. Brahmachari, J. Biol. Struct. Dyn., 2015, 33(1), 128
  • Prioritization of anticancer drugs against a cancer using genomic features of cancer cells: A step towards personalized medicine. Sudheer Gupta, Kumardeep Chaudhary, Rahul Kumar, Ankur Gautam, Jagpreet Singh Nanda, Sandeep Dhanda, Samir Brahmachari, and Gajendra Raghava. Nature Scientific Reports; 6, Article number: 23857 (2016) doi:10.1038/srep23857
  • Data Intensive Genome Level Analysis for Designing Non-Toxic Ligands against Drug Resistant Mycobacterium tuberculosis. Divneet Kaur, Rohit Vashisht, Rintu Kutum, Debashish Dash, & Samir K. Brahmachari. Sci Rep. (2017) 20:7:46595. doi: 10.1038/srep46595; PMID: 28425478.
  • Structure based drug discovery for designing leads for the non-toxic metabolic targets in multi drug resistant Mycobacterium tuberculosis. Divneet Kaur , Shalu Mathew , Chinchu G S Nair , Azitha Begum , Ashwin K Jainanarayan , Mukta Sharma , Samir K Brahmachari. J Transl Med. (2017);15(1):261. doi: 10.1186/s12967-017-1363-9. PMID: 29268770
  • A web-based resource for designing therapeutics against Ebola Virus. Sandeep Kumar Dhanda, Kumardeep Chaudhary, Sudheer Gupta, Samir Kumar Brahmachari and Gajendra P. S. Raghava. Sci Rep. (2016) 6:24782 doi: 10.1038/srep24782
  • A decade of OSDD for TB: role and outcomes. Nisha Chandran and Samir K. Brahmachari. Current Science (2018), 115, doi: 10.18520/cs/v115/i10/1858-1864